UV-induced unscheduled DNA synthesis in differentiated and dedifferentiated lymphocytes from human peripheral blood under the action of DNA-repair and -replication inhibitors

Genter, E.I.; Mikhel'son, V.M.; Zhestianikov, V.D.

Tsitologiia 31(2): 215-219


ISSN/ISBN: 0041-3771
PMID: 2734851
Accession: 041884729

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The UV-stimulated unscheduled synthesis (US) of DNA has been investigated in lymphocytes of human peripheral blood in correlation with the extent of differentiation under the action of inhibitors of DNA synthesis and repair: caffeine, hydroxyurea (HU), cytosine arabinoside (ara-C) and 3-methoxybenzamide (3-MB). The US of DNA was investigated in dedifferentiated (PGA-stimulated) and in differentiated (PGA-unstimulated) lymphocytes. Caffeine and HU inhibited US of DNA more intensely in PGA-stimulated cells, and ara-C and ara-C in combination with HU--in unstimulated cells. 3-MB enhanced US of DNA in PGA-stimulated (but not in PGA-unstimulated) lymphocytes.