+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ultrastructural abnormalities of the cilia in human nasal epithelia



Ultrastructural abnormalities of the cilia in human nasal epithelia



Nihon Jibiinkoka Gakkai Kaiho 94(7): 949-962



Nasal mucosal cilia were observed with electron microscope in 14 patients with immotile cilia syndrome (ICS), 9 with nasal papilloma (NP), 23 with sinobronchial syndrome (SB), 2 with sinusitis combined with dextrocardia (SC), 1 with Kartagener's syndrome (KS), and 5 normal controls (C). Abnormalities such as complex cilia, cilia with abnormal axonemes and cilia with randomly oriented central microtubules were frequently found in the groups of ICS (8.1%) and NP (10.4%) while less in other groups: SB (4.9%), SC (5.3%), KS (4.7%) and C (3.9%). The percentage of cilia with defective dynein arms (DA) was the highest in the ICS group (94.0%), followed by the groups of SC (53.7%), SB (47.5%), NP (41.2%), C (35.8%) and KS (33.3%). The ICS group was found to be the largest in the number of defective DA per a cilium (4.1), followed by the groups of NP (1.0), SB (0.6), SC (0.7), KS (0.4) and C (0.4). Increased rates of defective DA were also recognized in cilia of tracheal mucosa and flagella of sperm in 7 patients with ICS examined. In conclusion, neither abnormal cilia nor defective DA of cilia are specific findings for ICS. However, when we observe these findings in high percentage in nasal mucosa as well as in other organs, we may define this condition as ICS.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041889369

Download citation: RISBibTeXText

PMID: 1919862

DOI: 10.3950/jibiinkoka.94.949


Related references

Immotile cilia syndrome ultrastructural abnormalities of nasal cilia. Acta Oto-Rhino-Laryngologica Belgica 43(5): 514-521, 1989

The significance of ultrastructural abnormalities of human cilia. Chest 80(6 Suppl): 796-799, 1981

Immotile cilia syndrome--ultrastructural deviations of the nasal cilia. Acta Oto-Rhino-Laryngologica Belgica 43(5): 515-521, 1989

Ultrastructural abnormalities of cilia in the human respiratory tract. Human Pathology 17(8): 848-855, 1986

Pathological and ultrastructural observation on the epithelia of nasal cavity and nasal sinuses in chronic sinusitis and nasal polyps after endoscopic sinus surgery. Lin Chuang Er Bi Yan Hou Ke Za Zhi 19(20): 923-925, 2005

Variations in the ultrastructure of human nasal cilia including abnormalities found in retinitis pigmentosa. Journal of Clinical Pathology 33(4): 327-335, 1980

Ultrastructural changes in human nasal cilia caused by the common cold and recovery of ciliated epithelium. Annals of Otology Rhinology and Laryngology 101(12): 982-987, 1992

An ultrastructural and functional assessment of nasal cilia and spermatozoa in an infertile human male and healthy controls. Papers and Proceedings of the Royal Society of Tasmania 138(October 29): 1-10, 2004

Immotile cilia syndrome: nasal mucociliary function and nasal ciliary abnormalities. Rhinology 32(3): 109-111, 1994

Necklaces of primary and secondary cilia in developing rat nasal epithelia. Journal of Cell Biology 105(4 Part 2): 34A, 1987

Genesis of cilia and microvilli of rat nasal epithelia during pre-natal development. I. Olfactory epithelium, qualitative studies. Journal of Cell Science 78: 283-310, 1985

Genesis of cilia and microvilli of rat nasal epithelia during pre-natal development. II. Olfactory epithelium, a morphometric analysis. Journal of Cell Science 78: 311-336, 1985

Lectins bind differentially to cilia and microvilli of major and minor cell populations in olfactory and nasal respiratory epithelia. Microscopy Research and Technique 23(2): 181-199, 1992

Transitory ultrastructural abnormalities of cilia. British Journal of Diseases of the Chest 76(2): 185-188, 1982

Qualitative and quantitative freeze fracture studies on cilia and micro villi of the olfactory and nasal respiratory epithelia of 4 vertebrate species. Ultramicroscopy 5(1): 122, 1980