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Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies



Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies



International Journal of Peptide and Protein Research 37(4): 341-346



The Mpc-group has a somewhat better stability than the Fmoc-group, resists catalytic hydrogenolysis, is highly stable in acidic media and its elimination product does not polymerize spontaneously. In a direct comparison of coupling efficiencies obtained in solid phase peptide syntheses using Mpc- or Fmoc-amino acids it is shown that the use of Mpc-amino acids leads to better coupling efficiencies and, consequently, a more homogeneous peptide. An improved synthesis of Mpc-ONSu and of Mpc-amino acid derivatives is presented.

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Accession: 041912674

Download citation: RISBibTeXText

PMID: 1894449

DOI: 10.1111/j.1399-3011.1991.tb00748.x


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