Use of sequential analysis in clinical trials of caries prophylactic agents

Smith, V.O.; O'Mullane, D.M.

Journal of Dental Research 56(Special Issue): C112-C115


ISSN/ISBN: 0022-0345
PMID: 273021
DOI: 10.1177/002203457705600302011
Accession: 041923302

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Using a sequential t test, the objectives of two 3-year experimental clinical trials were achieved more efficiently by using fewer subjects over a shorter time. The assumption of identical distributions of each batch of data analyzed was not apparent and further work to establish the robustness of sequential t tests is indicated. Identification of subjects with more consistent caries increments during the period of a trial would also help to satisfy this assumption.