+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Value of serum levels of carcinoembryonic antigen, CEA, and gastrointestinal cancer antigen, GICA or CA 19-9, for preoperative staging and postoperative monitoring of patients with colorectal carcinoma



Value of serum levels of carcinoembryonic antigen, CEA, and gastrointestinal cancer antigen, GICA or CA 19-9, for preoperative staging and postoperative monitoring of patients with colorectal carcinoma



Diseases of the Colon and Rectum 28(12): 895-899



Serum levels of gastrointestinal cancer antigen (GICA) and carcinoembryonic antigen (CEA) were determined in 167 patients with colorectal carcinoma. Eighty-eight patients were studied preoperatively, and 79 postoperatively, before, at the time of, and after the diagnosis of relapse. The authors aimed to assess how often the GICA test failed, i.e., was false-negative in patients in whom the CEA test was true-positive and, more importantly, whether it could give diagnostic information in patients in whom the CEA test failed. Before surgery, serum GICA gave similar information to serum CEA in 56 percent of the patients: true-positive in 18 percent and false-negative in 38 percent; less information in 42 percent; and more information in only 2 percent. During the postoperative follow-up, serum GICA gave similar information to serum CEA in 55 percent of the patients: true-positive (i.e., rising persistently from a postoperative nadir) in 27 percent and false-negative in 28 percent; less information in 44 percent; and more information in only 1 percent. Therefore, this test in its present version, where both the catcher and the tracer antibody are the same, NS 19-9, is redundant.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041937784

Download citation: RISBibTeXText

PMID: 3864628

DOI: 10.1007/bf02554298


Related references

Value of serum levels of carcinoembryonic antigen and gastrointestinal cancer antigen ca 19 9 for preoperative staging and postoperative monitoring of patients with colorectal carcinoma. Diseases of the Colon & Rectum 28(12): 895-899, 1985

Serum levels of carcinoembryonic antigen, gastrointestinal cancer-associated antigen and alphafetoprotein in staging and management of patients with advanced carcinoma of the stomach. International Journal of Biological Markers 2(1): 19-24, 1987

Accuracy of monitoring serum carcinoembryonic antigen levels in postoperative stage III colorectal cancer patients is limited to only the first postoperative year. Surgery Today 41(10): 1357-1362, 2011

Carcinoembryonic antigen and breast carcinoma antigen (CA 15.3) in preoperative staging and postoperative monitoring of patients with carcinoma of the breast. International Journal of Biological Markers 3(3): 165-171, 1988

Inflammation-based prognostic system predicts postoperative survival of esophageal carcinoma patients with normal preoperative serum carcinoembryonic antigen and squamous cell carcinoma antigen levels. World Journal of Surgical Oncology 14: 141, 2016

Imaging with indium111-labeled anticarcinoembryonic antigen monoclonal antibody ZCE-025 of recurrent colorectal or carcinoembryonic antigen-producing cancer in patients with rising serum carcinoembryonic antigen levels and occult metastases. Journal of Clinical Oncology 8(7): 1246-1254, 1990

Colorectal carcinoma liver metastases: Clinical significance of preoperative measurement of serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels. International Journal of Colorectal Disease 16(1): 32-37, 2001

Preoperative carcinoembryonic antigen levels correlated with postoperative pathological staging in bronchial carcinoma. Thorax 35(12): 920-924, 1980

Technetium 99m-labeled IMMU-4, a monoclonal antibody against carcinoembryonic antigen, for imaging of occult recurrent colorectal cancer in patients with rising serum carcinoembryonic antigen levels. Journal of Clinical Oncology 12(3): 489-495, 1994

Prognostic significance of pre- and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 39(4): 245-250, 2007

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment. Bmc Cancer 9: 288, 2009

Evaluation of serum carcinoembryonic antigen monitoring in the follow-up of colorectal cancer patients with metastatic lymph nodes and a normal preoperative serum level. International Journal of Biological Markers 12(1): 18-21, 1997

Tumor-associated glycoprotein-72 serum levels complement carcinoembryonic antigen levels in monitoring patients with gastrointestinal carcinoma. A longitudinal study. Cancer 68(11): 2443-2450, 1991

Is decrement ratio between preoperative and postoperative serum carcinoembryonic antigen level considered as a predictive prognostic indicator in colorectal cancer patients?. International Journal of Cancer Suppl. (13): 224, 2002

160Psignificance of serum carcinoembryonic antigen despite normal preoperative levels in colorectal cancer patients receiving curative resection. Annals of Oncology 26(Suppl 9): ix49.1-ix49, 2015