+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Verapamil as a co-mutagen in the Salmonella/mammalian microsome mutagenicity test

Verapamil as a co-mutagen in the Salmonella/mammalian microsome mutagenicity test

Mutation Research 209(1-2): 57-62

Verapamil is a calcium-channel blocking agent, commonly used for chronic treatment of heart conditions. We have previously demonstrated that verapamil acts as a co-mutagen in a bacterial mutagenicity test for some experimental anilinoacridine antitumour drugs. Within the anilinoacridines series there are several compounds which are apparently non-mutagenic (or very weak mutagens) in the absence of verapamil, but strong mutagens in its presence. We have now tested a wider range of materials for verapamil enhancement of mutagenicity, to include some of those to which persons on verapamil therapy might be exposed through life-style or occupation. Some verapamil enhancement of mutagenicity was seen with most mutagenic compounds including anticancer drugs, antiparasitic agents, one biological stain and one hair dye. A number of tricyclic antidepressants and biological stains were tested and found to be non-mutagenic. If these results extrapolate to mammalian cells, long-term verapamil therapy could potentially increase the effects of certain environmental mutagens.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 041951225

Download citation: RISBibTeXText

PMID: 3050506

DOI: 10.1016/0165-7992(88)90111-x

Related references

Mutagenicity of chloro-olefins in the Salmonella/mammalian microsome test. I. Allyl chloride mutagenicity re-examined. Mutation Research 157(2-3): 145-148, 1985

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test. Mutation Research 68(3): 211-216, 1979

Protacine. Absence of mutagenicity on Salmonella/mammalian microsome test. Il Farmaco; Edizione Pratica 33(12): 543-546, 1978

Mutagenicity test of dyes used in cosmetics with the Salmonella/mammalian-microsome test. Mutation Research 67(1): 1-8, 1979

4-Chloro-3-methylphenol: Salmonella/mammalian-microsome mutagenicity test and subacute toxicity test in rats. Bulletin of Environmental Contamination and Toxicology 37(5): 651-654, 1986

The Ames test: a look at the Salmonella/mammalian microsome mutagenicity test. Veterinary and Human Toxicology 22(1): 23-25, 1980

Use of the salmonella and mammalian microsome mutagenicity test for detecting potential carcinogens. Igiene Moderna 81(4): 880-891, 1984

Mutagenicity of N-nitroso pyridinol carbamate with the Salmonella/mammalian microsome test. Cancer Letters 7(2-3): 135-139, 1979

Mutagenicity of bithionol sulfoxide and its metabolites in the salmonella/mammalian microsome test. Mutation Research 188(1): 53-55, 1987

Mutagenicity of cosmetic dyes using the salmonella typhimurium mammalian microsome test. Abstracts of the Annual Meeting of the American Society for Microbiology 78 : 204, 1978

Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test. Environmental Mutagenesis 2(1): 59-66, 1980

Mutagenicity of pyrolytic products of korean animal protein foods by salmonella mammalian microsome test 1. mutagenicity of korean style beef bulgogi. Environmental Mutagens and Carcinogens 7(2): 85-102, 1987

Mutagenicity of n nitroso pyridinol carbamate with the salmonella typhimurium mammalian microsome test. Cancer Letters 7(2-3): 135-140, 1979

Mutagenicity testing of smoke flavor preparations in salmonella mammalian microsome test. Mutation Research 64(2): 135-137, 1979

Bile acids co mutagenic activity in the salmonella mammalian microsome mutagenicity test. Journal of the National Cancer Institute 59(5): 1557-1560, 1977