Weakening of the ultraviolet ray-induced unscheduled DNA synthesis in human lymphocytes in extreme old age

Lezhava, T.A.; Prokof'eva, V.V.; Mikhel'son, V.M.

Tsitologiia 21(11): 1360-1363


ISSN/ISBN: 0041-3771
PMID: 524461
Accession: 041969164

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The intensity of unscheduled DNA synthesis was studied in UV-irradiated (10--15 J/m2) peripheral blood lymphocytes of 80--90 years old persons. In these extreme old age persons, reparative DNA synthesis was found sufficiently reduced in comparison with that in middle aged (20--43 years old) ones. The role of DNA repair processes in ageing is under discussion.