3H]noradrenaline release evoked by selegiline ( (-) -deprenyl) in the isolated main pulmonary artery of the rabbit
Török, T.L.; Bunyevácz, Z.; Nguyen, T.T.; Magyar, K.
Journal of Pharmacy and Pharmacology 36(2): 107-110
ISSN/ISBN: 0022-3573 PMID: 6143793 DOI: 10.1111/j.2042-7158.1984.tb03003.x
High concentrations of selegiline[-)-deprenyl) (greater than 10(-5) M) enhanced the nerve stimulation (2 Hz)-evoked release of [3H]noradrenaline from the isolated main pulmonary artery of the rabbit. This facilitation of stimulation-evoked [3H]noradrenaline release by selegiline was reduced by exogenous (-)-noradrenaline, an agonist of presynaptic alpha 2-adrenoceptors. This inhibitory action of (-)-noradrenaline was partly antagonized by yohimbine, a selective alpha 2-adrenoceptor blocker. When the stimulation-evoked [3H]noradrenaline release had already been increased by inhibition of Na+-pump (K+-free solution), selegiline further enhanced the nerve-evoked release of labelled neurotransmitter.