EurekaMag
+ Translate
+ Most Popular
Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout
The parasites of British birds and mammals. 3XIV-3XVH
Studies on the in vitro synthesis of phi x 174 super helical covalently closed circular duplex dna and circular single stranded dna
The Shahada movement: a peasant movement in Maharashtra (India) - its development and its perspectives
The cranial nerves of Wallago attu
Anatomy of Mystus seenghala IV Nervous system
Haematology of Persian fallow deer (Dama mesopotamica)
Major weeds of rabi and kharif crops and their control
Structure of Morija-Banol iron-ore deposits, Rajasthan, and its control over mineralization
Donkioporia expansa - A lesser known wood destroyer in buildings
The new physiology of vision 3Xin. The testing of color-vision
Economic importance of Pteridophytes
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Ketoconazole shampoo 1% vs. climbazole shampoo in the treatment of seborrhoeic scalp dermatitis
Economic efficiency of biwall drip irrigation in sugarcane production - a case study in Ankalkhop village in Sangli District of Maharashtra
48,4X-49,5X mosaic: asynchronies among the late-replicating X chromosomes
Compatibility of potassium phosphonate (Akomin-40) with different species of Trichoderma and Gliocladium virens
Enterobacter amnigenus. An unusual human pathogen
The 48 4X 49 4Xy 49 4X iso chromosome yq mosaicism in a 3 year old boy from a twin pregnancy
Placentrex treatment in corneal defects in animals
The biology of human starvation: some new insights
Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA
Replenishable but depletable resources: water
New insights into bestiality and zoophilia
Thoracic outlet syndrome in Ehlers-Danlos patients as displayed by magnetic resonance imaging, angiography and venography

A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling


A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling



Pharmatherapeutica 3(8): 526-530



ISSN/ISBN: 0308-051X

PMID: 6366808

A multi-centre, double-blind, placebo-controlled trial was carried out to investigate the clinical efficacy of the anti-inflammatory enzyme serrapeptase in a total of 174 patients who underwent Caldwell-Luc antrotomy for chronic empyema. Eighty-eight patients received 10 mg serrapeptase 3 times on the day before operation, once on the night of the operation and 3 times daily for 5 days after operation; the other 86 received placebo. Changes in buccal swelling after operation were observed as a parameter of the response to treatment. The degree of swelling in the serrapeptase-treated patients was significantly less than that in the placebo-treated patients at every point of observation after operation up to the 5th day (p less than 0.01 to p less than 0.05). Maximal swelling throughout all the post-operative points of observation was also significantly smaller in size in the serrapeptase-treated group than in the placebo-treated group. No side-effects were reported.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042080843

Download citation: RISBibTeXText

Related references

Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study. Multiple Sclerosis 16(11): 1360-1366, 2010

Comparative effects of two different calcipotriol (MC 903) cream formulations versus placebo in psoriasis vulgaris. A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Multi-Centre Study. Journal of the European Academy of Dermatology and Venereology 6(2): 152-158, 1996

Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Annals of the Rheumatic Diseases 67(8): 1096-1103, 2008

A double-blind, placebo controlled, multi-centre study of tacrine for Alzheimer's disease. Neurobiology of Aging 15: S99-S100, 1994

Flunarizine (10 and 20 mg) I. V. versus placebo in the treatment of acute migraine attacks: a multi-centre double-blind study. Cephalalgia 10(2): 77-81, 1990

Treatment of Peripheral Circulatory Disturbances with Cinnarizine: A Multi-centre Double-blind, Placebo-controlled Evaluation. Proceedings of the Royal Society of Medicine 70(Suppl 8): 17-20, 1977

Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study. Cerebrovascular Diseases 21(5-6): 380-385, 2006

Acamprosate in Korean alcohol-dependent patients: a multi-centre, randomized, double-blind, placebo-controlled study. Alcohol and Alcoholism 38(2): 135-141, 2003

A Multi-Centre Double Blind Crossover Comparison of Disopyramide, Atenolol, and Placebo for Symptomatic Paroxysmal Atrial Fibrillation. Journal of the American College of Cardiology 1995(SPEC ISSUE): 231A, 1995

Evaluation of safety and immunogenicity of HNVAC, an MDCK-based H1N1 pandemic influenza vaccine, in Phase I single centre and Phase II/III multi-centre, double-blind, randomized, placebo-controlled, parallel assignment studies. Vaccine 32(35): 4592-4597, 2014

Naltrexone versus acamprosate in the treatment of alcohol dependence: A multi-centre, randomized, double-blind, placebo-controlled trial. Addiction 101(10): 1451-1462, 2006

Sublingual immunotherapy A multi-centre randomised double blind placebo-controlled study with birch and grass pollen extracts. Immunology 98(Suppl 1): 140, 1999

A multi-centre randomised double-blind placebo-controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT colonography. Bmc Gastroenterology 13: 94, 2013

Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial. Beneficial Microbes 8(4): 569-578, 2017

A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome. Intensive Care Medicine 27(10): 1578-1583, 2001