Section 43
Chapter 42,085

A new case of gamma-heavy chain disease. Clinical and immunochemical studies

Cozzolino, F.; Vercelli, D.; Castigli, E.; Becucci, A.; Di Guglielmo, R.

Scandinavian Journal of Haematology 28(2): 145-150


ISSN/ISBN: 0036-553X
PMID: 6806895
DOI: 10.1111/j.1600-0609.1982.tb00507.x
Accession: 042084006

Download citation:  

The detection of a γ-heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, Mw 66000, beginning at Asp 221 residue in the hinge region. No clinical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high-dose anti-neoplastic treatments and of immunological impairment.

PDF emailed within 0-6 h: $19.90