+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma



A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma



Archives of Ophthalmology 101(12): 1894-1899



Prognostic indicators of uveal melanoma disease-free interval and survival following enucleation were evaluated for 267 patients. The median follow-up time was 17 years. Analysis involved Kaplan-Meier survival curves based on time to tumor-related deaths and multivariate proportional hazards analysis, which provides an estimate of the "force of mortality." Prognostic indicators considered included demographic, clinical, and histopathological factors. Cell type was classified according to the number of epithelioid cells present per high-power field (HPF) on light microscopy. Various classifications of size of the tumor were compared for prognostic value. The five leading predictors of survival in order of importance were as follows: (1) number of epithelioid cells per HPF, (2) largest dimension of the tumor, (3) location of the anterior margin of the tumor, (4) invasion to the line of transection, and (5) degree of pigmentation. Risk categories for survival were constructed based on the three leading prognostic factors.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 042101141

Download citation: RISBibTeXText

PMID: 6651594

DOI: 10.1001/archopht.1983.01040020896012


Related references

Metastasis-free survival following treatment for uveal melanoma with either stereotactic radiosurgery or enucleation. Acta Ophthalmologica Scandinavica 81(4): 383-388, 2003

Cobalt plaque radiotherapy versus enucleation for posterior uveal melanoma: comparison of survival by prognostic index groups. Transactions of the American Ophthalmological Society 87: 348-59; Discussion 359-61, 1989

Micrometastasis of a sentinel lymph node in cutaneous melanoma is a significant prognostic factor for disease-free survival, distant-metastasis-free survival, and overall survival. Dermatologic Surgery 30(10): 1319-1328, 2004

Micrometastasis of a Sentinel Lymph Node in Cutaneous Melanoma Is a Significant Prognostic Factor for Disease-Free Survival, Distant-Metastasis-Free Survival, and Overall Survival. Dermatologic Surgery 30(10): 1319-1328, 2004

Prognostic indicators following enucleation for posterior uveal melanoma. A multivariate analysis of long-term survival with minimized loss to follow-up. Acta Ophthalmologica Scandinavica 73(4): 340-344, 1995

Effect of Pre-Enucleation Irradiation on the Survival of Patients with Uveal Melanoma. Ophthalmologica 212(4): 231-235, 1998

Effect of pre-enucleation irradiation on the survival of patients with uveal melanoma. Ophthalmologica. Journal International d'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift für Augenheilkunde 212(4): 231-235, 1998

Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma. Clinical Cancer Research 13(4): 1171-1178, 2007

No demonstrated effect of pre-enucleation irradiation on survival of patients with uveal melanoma. American Journal of Ophthalmology 119(6): 786-791, 1995

Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates. British Journal of Ophthalmology 72(7): 494-497, 1988

Does enucleation constitute a risk factor in malignant uveal melanoma?. Revista de Chirurgie, Oncologie, Radiologie, O. R. L., Oftalmologie, Stomatologie. Seria: Oftalmologie 25(2): 135-138, 1981

Survival analysis of uveal melanoma with extrascleral extension for comparison between enucleation and exenteration end results. Investigative Ophthalmology & Visual Science 29(ABSTR ISSUE): 333, 1988

Ultrasonic tissue characterization of uveal melanoma and prediction of patient survival after enucleation and brachytherapy. American Journal of Ophthalmology 112(6): 682-688, 1991

Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma. Yearbook of Ophthalmology 2010: 231-232, 2010

Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. American Journal of Ophthalmology 99(3): 282-290, 1985