+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Active calcium and sodium transport by cardiac plasma membranes in the genetically hypertensive rat

Active calcium and sodium transport by cardiac plasma membranes in the genetically hypertensive rat

Archives des Maladies du Coeur et des Vaisseaux 77(11): 1261-1265

Active Na+ and Ca2+ transports by sarcolemmal vesicles from young spontaneously hypertensive rats (SHR) and their normotensive controls (WKY) were compared. The effects of the calmodulin and the calcium antagonist nifedipine on Ca2+ binding ATP-dependent accumulation of Ca2+ were studied at free Ca2+ concentrations of 2.10(-8)M and 4.10(-7)M. 2.10(-7)M calmodulin stimulated Ca2+ binding to SHR membranes up to a level equivalent to that in WKY, whereas it enhanced active Ca2+ transport more in WKY than in SHR, thus suppressing the difference between the two substrains. At a 2.10(-8)M free Ca2+ concentration low concentrations of nifedipine (10(-7) to 10(-6)M) induced an increases in ATP-dependent Ca2+ transport by SHR vesicles. Inhibition of NA+, K+-adenosine triphosphatase activity by ouabain was also studied. Na+, K+ATPase activity in SHR membranes was double that in membranes from WKY (22.1 +/- 2.8 v.s. 11.3 +/- 1.1. mumole Pi/h/mg protein). These differences, observed on 3 week-old rats, before a significant rise blood pressure, may reflect genetic characteristics of these hypertensive-prone rats.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 042166802

Download citation: RISBibTeXText

PMID: 6098237

Related references

Calcium transport in isolated renal plasma membranes from milan strain of genetically hypertensive rats. Experientia (basel): 713, 1987

Atp dependent calcium transport and sodium calcium exchange system in renal basolateral plasma membranes of spontaneously hypertensive rats. Clinical & Experimental Hypertension Part A Theory & Practice 7(12): 1719-1732, 1985

Altered active sodium and calcium transport by heart sarcolemmal membranes from young spontaneously hypertensive rats: modulation by calmodulin. Journal of Hypertension. Supplement 2(3): S485-S487, 1984

High-affinity calcium binding in rat synaptosomal plasma membranes: decrease in young, genetically hypertensive rats. Journal of Neurochemistry 38(5): 1342-1347, 1982

Interactions of cardiac glycosides with cells and membranes. Therapeutic and toxic doses of ouabain acting on sodium and calcium pumps in plasma membranes. Biochemical Pharmacology 37(11): 2293-2297, 1988

Calcium transport and protein content in cell plasma membranes of spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 6(Suppl. 1): S21-S27, 1984

Calcium transport in basolateral plasma membranes from kidney cortex of Milan hypertensive rats. Biochimica et Biophysica Acta 941(2): 187-197, 1988

L glutamic acid sodium and potassium dependency for transport across jejunal brush border membranes of chickens genetically selected for low and high l leucine transport activity across erythrocyte membranes. Federation Proceedings 44(3): 803, 1985

Abnormal regulation of calcium transport in renal basolateral plasma membranes of Milan hypertensive rats. Progress in Clinical and Biological Research 252: 371-377, 1988

Effect of plasma from hypertensive patients and controls on red cell sodium and calcium transport. Proceedings of the University of Otago Medical School 62(1): 16-17, 1984

The cyclic amp dependent control of active transport of calcium in plasma membranes of pig myometrium. Biokhimiya 52(10): 1618-1623, 1987

Calcium at the surface of cardiac plasma membranes cation binding surface charge screening and sodium calcium exchange. Biophysical Journalpart 2: 491a, 1985

Inhibition of an active calcium transport system in cardiac sarcolemma by ouabain involvement of sodium and potassium. Naunyn-Schmiedeberg's Archives of Pharmacology 313(Suppl.): R41, 1980

Modification of platelet and lymphocyte calcium handling and blood pressure by dietary sodium and calcium in genetically hypertensive rats. Journal of Laboratory and Clinical Medicine 119(2): 151-158, 1992

In vitro active intestinal calcium transport of wistar kyoto spontaneously hypertensive rats shr and normotensive controls is not influenced by level of oral sodium chloride intake. Clinical Research 37(2): 394A, 1989