An inhibitory protein of Escherichia coli RNA polymerase in bacteriophage T3-infected cells (core polymerase-sigma factor-host polymerase-phage polymerase-initiation)

Mahadik, S.P.; Dharmgrongartama, B.; Srinivasan, P.R.

Proceedings of the National Academy of Sciences of the United States of America 69(1): 162-166

1972


ISSN/ISBN: 0027-8424
PMID: 4550502
DOI: 10.1073/pnas.69.1.162
Accession: 042248016

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Abstract
A partially purified protein isolated from bacteriophage T3-infected cells of Escherichia coli B markedly inhibits the activity of E. coli RNA polymerase, slightly inhibits the activity of purified T3 polymerase, and does not inhibit the activity of either core polymerase or the ribosome-bound T3 polymerase. The properties of this protein and its mechanism of action have been studied. It appears to antagonize the action of the sigma factor component of RNA polymerase.