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Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE



Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE



Agents and Actions 11(1-2): 100-102



Peritoneal mast cells from rats of BH- and DA-inbred strains were compared for their capacity to passive sensitization in vitro with mouse IgE antibodies. In identical experimental conditions mast cells of BH-rats were good receptors for mouse IgE anti-KLH fraction and released histamine when challenged with specific antigen, whereas mast cells of DA-rats were much less sensitized and released little histamine on the challenge. In contrast, mast cells of DA-rats wee more susceptible to the challenge with anti-rat IgE and Concanavalin A, than were cells of BH-rats. This susceptibility correlated with total serum IgE level, which was higher in DA- than in BH-rats. These results show higher concentrations of IgE on mast cells of DA--rats. It is suggested that rat IgE present on normal mast cells may be one of the factors interfering in in vitro sensitization of the cells from DA-rats with mouse IgE antibodies.

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Accession: 042265592

Download citation: RISBibTeXText

PMID: 6166159

DOI: 10.1007/bf01991470


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