+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibody-dependent and spontaneous cell-mediated cytotoxicity against transmissible gastroenteritis virus infected cells by lymphocytes from sows, fetuses and neonatal piglets



Antibody-dependent and spontaneous cell-mediated cytotoxicity against transmissible gastroenteritis virus infected cells by lymphocytes from sows, fetuses and neonatal piglets



Canadian Journal of Comparative Medicine 48(3): 258-261



The purpose of this study was to investigate the ontogeny in the pig of effector lymphocytes mediating antibody-dependent and spontaneous cell-mediated cytotoxicity against target cells infected with transmissible gastroenteritis virus. The same activities were also studied in sows in late pregnancy and early lactation. Peripheral blood lymphocytes and intraepithelial lymphocytes collected from piglets during the first week of life failed to mediate cytolysis as determined by chromium release assays, but significant activities developed during the second week and usually increased further by the sixth week. Peripheral blood lymphocytes collected from fetuses on the 109th gestation day failed to produce spontaneous cell-mediated cytotoxicity and only reacted in antibody-dependent cell-mediated cytotoxicity when contaminated with macrophages. The cytotoxic activities of peripheral blood lymphocytes from sows were lowest at parturition. It was concluded that impaired lymphocyte cytotoxicity in newborn piglets and parturient sows may contribute to their relatively high susceptibility to transmissible gastroenteritis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042290788

Download citation: RISBibTeXText

PMID: 6332661


Related references

Antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against cells infected with porcine transmissible gastroenteritis virus. Canadian Journal of Comparative Medicine 47(3): 298-303, 1983

Characterization of the effector cells in antibody dependent and spontaneous cell mediated cytotoxicity in swine against target cells infected with transmissible gastroenteritis virus. Research in Veterinary Science 41(1): 70-75, 1986

Effect of adoptive transfer of mononuclear leukocytes from an adult donor on spontaneous cell mediated cytotoxicity and resistance to transmissible gastroenteritis in neonatal piglets. Canadian Journal of Comparative Medicine 48(4): 360-364, 1984

Characterization with monoclonal antibodies of human lymphocytes active in natural killing and antibody-dependent cell-mediated cytotoxicity of dengue virus-infected cells. Immunology 58(3): 429-436, 1986

The role of target cells, monocytes, and Fc receptor-bearing lymphocytes in human spontaneous cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity. Journal of Immunology 125(1): 396-405, 1980

Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. Journal of Virology 52(1): 223-230, 1984

Upper respiratory infection of lactating sows with transmissible gastroenteritis virus following contact exposure to infected piglets. Cornell Veterinarian 65(3): 352-362, 1975

Fluid therapy trials in neonatal piglets infected with transmissible gastroenteritis virus. Canadian Journal of Comparative Medicine 49(4): 357-360, 1985

Hypoglycemia: a factor associated with low survival rate of neonatal piglets infected with transmissible gastroenteritis virus. Canadian Journal of Comparative Medicine 48(3): 282-285, 1984

Lysis of autologous virus infected cells by direct cytotoxicity and antibody-dependent cell-mediated cytotoxicity in lentiviral infection: equine infectious anemia. Periodicum Biologorum 92(1): 45-46, 1990

Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells. Journal of Infectious Diseases 148(5): 785-794, 1983

Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) to Measles Virus Infected Cells. Pediatrics International 23(2): 251-251, 1981

Antibody-Dependent Cell-Mediated Cytotoxicity Against Cells Infected with the Human Immunodeficiency Virus. Journal of Infectious Diseases 156(6): 878-884, 1987

Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus. Journal of Infectious Diseases 156(6): 878-884, 1987

Experimental immunisation of sows against transmissible gastroenteritis. I. Immunisation with a bacteria-free suspension of transmissible gastroenteritis virus prepared from the intestines of infected pigs. Veterinary Record 87(3): 62-64, 1970