+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells

Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells

Journal of Infectious Diseases 148(5): 785-794

The three major immunocompetent cells in human peripheral blood (lymphocytes, neutrophils, and monocytes) were shown to be effector cells for antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza virus-infected baby hamster kidney cells in vitro. Lymphocyte cytotoxicity was mediated by FcIgG receptor-bearing null cells and T gamma cells. These effector populations were best defined by HNK-1, a monoclonal antibody to human natural killer and ADCC-mediator cells. Antibody responsible for ADCC against influenza virus-infected cells was detectable in sera of young children after natural infection and after vaccination with inactivated and live attenuated viruses. ADCC antibody appeared before hemagglutination-inhibiting antibody and persisted for at least one year after vaccination with live attenuated vaccine. ADCC antibody was subtype-specific but quite broadly reactive within a subtype. Both hemagglutinin and neuraminidase were antigenic determinants for ADCC antibody. An anamnestic response to the original strain was observed after challenge with influenza virus of a heterologous subtype.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 042290804

Download citation: RISBibTeXText

PMID: 6605395

DOI: 10.1093/infdis/148.5.785

Related references

Antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against cells infected with porcine transmissible gastroenteritis virus. Canadian Journal of Comparative Medicine 47(3): 298-303, 1983

Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. Journal of Virology 52(1): 223-230, 1984

Lysis of autologous virus infected cells by direct cytotoxicity and antibody-dependent cell-mediated cytotoxicity in lentiviral infection: equine infectious anemia. Periodicum Biologorum 92(1): 45-46, 1990

Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) to Measles Virus Infected Cells. Pediatrics International 23(2): 251-251, 1981

Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus. Journal of Infectious Diseases 156(6): 878-884, 1987

Human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus. Clinical and Experimental Immunology 28(1): 19-26, 1977

Characterization of the effector cells in antibody dependent and spontaneous cell mediated cytotoxicity in swine against target cells infected with transmissible gastroenteritis virus. Research in Veterinary Science 41(1): 70-75, 1986

Macrophages bind directly to Semliki Forest virus-infected cells and mediate antibody-dependent cell-mediated cytotoxicity. Australian Journal of Experimental Biology and Medical Science 62: 193-197, 1984

Antibody-dependent cell-mediated cytotoxicity against cells infected with respiratory syncytial virus: characterization of in vitro and in vivo properties. Journal of Immunology 122(6): 2521-2526, 1979

Antibody-dependent cell-mediated cytotoxicity to herpes simplex virus type 2 infected target cells in the course of cervical carcinoma. American Journal of Epidemiology 108(2): 126-135, 1978

Scanning electron microscopy of antibody-dependent cell-mediated cytotoxicity of Friend leukemia virus-infected spleen cells. Experientia 35(6): 832-833, 1979

Antibody reactive in antibody-dependent cell-mediated cytotoxicity following influenza virus vaccination. Journal of Medical Virology 6(3): 203-211, 1980

Peste des Petits Ruminants Virus Fusion and Hemagglutinin Proteins Trigger Antibody-Dependent Cell-Mediated Cytotoxicity in Infected Cells. Frontiers in Immunology 9: 3172, 2018

Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity. Journal of Virology 89(20): 10648-10655, 2015

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice. Frontiers in Immunology 8: 317, 2017