+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against cells infected with porcine transmissible gastroenteritis virus



Antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against cells infected with porcine transmissible gastroenteritis virus



Canadian Journal of Comparative Medicine 47(3): 298-303



The objective of this study was to determine whether porcine peripheral blood leukocytes and intestinal intraepithelial leukocytes can mediate antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against target cells infected with transmissible gastroenteritis virus. Peripheral blood leukocytes collected from six young adult pigs and intraepithelial leukocytes from a further five pigs were used as effector cells in chromium release assays against PK-15 cells persistently infected with transmissible gastroenteritis virus. Both peripheral blood leukocytes and intraepithelial leukocytes were capable of mediating antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against PK-15 transmissible gastroenteritis cells. While the peripheral blood leukocytes mediated lower levels of specific 51Cr release in spontaneous cell-mediated cytotoxicity than in antibody-dependent cell-mediated cytotoxicity, the intraepithelial leukocytes were more effective in spontaneous cell-mediated cytotoxicity than antibody-dependent cell-mediated cytotoxicity.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042290807

Download citation: RISBibTeXText

PMID: 6315197


Related references

Antibody-dependent and spontaneous cell-mediated cytotoxicity against transmissible gastroenteritis virus infected cells by lymphocytes from sows, fetuses and neonatal piglets. Canadian Journal of Comparative Medicine 48(3): 258-261, 1984

Characterization of the effector cells in antibody dependent and spontaneous cell mediated cytotoxicity in swine against target cells infected with transmissible gastroenteritis virus. Research in Veterinary Science 41(1): 70-75, 1986

Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. Journal of Virology 52(1): 223-230, 1984

Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity. Transplantation 62(1): 105-113, 1996

Inhibition of spontaneous but not antibody-dependent cell-mediated cytotoxicity by simple sugars: evidence that endogenous lectins may mediate spontaneous cell-mediated cytotoxicity. Immunology 44(1): 143-152, 1981

Lysis of autologous virus infected cells by direct cytotoxicity and antibody-dependent cell-mediated cytotoxicity in lentiviral infection: equine infectious anemia. Periodicum Biologorum 92(1): 45-46, 1990

Antibody dependent cell mediated cytotoxicity toward human o positive red cells coated with anti d antibody comparison between lymphocyte and monocyte antibody dependent cell mediated cytotoxicity activity. Acta Medica Okayama 39(2): 77-90, 1985

Spontaneous lymphocyte-mediated cytotoxicity and antibody-dependent cell cytotoxicity of human effector cells. Folia Haematologica 110(6): 831-842, 1983

Porcine effector mechanisms: antibody-dependent cell-mediated cytotoxicity of pseudorabies-infected target cells. Veterinary Immunology and Immunopathology 14(3): 223-231, 1987

Monocyte-mediated antibody-dependent cell-mediated cytotoxicity and spontaneous cytotoxicity in normals and cancer patients as assayed by human erythrocyte lysis. Cancer Research 43(9): 4504-4510, 1983

In vitro cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity to the transmissible venereal tumor of the dog. Journal of the National Cancer Institute 64(2): 317-321, 1980

Aging influence on the E-rosette forming cells, spontaneous cell mediated cytotoxicity, and antibody dependent cellular cytotoxicity in humans. Archivum Immunologiae et Therapiae Experimentalis 35(1): 1-10, 1987

Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells. Journal of Infectious Diseases 148(5): 785-794, 1983

Follow-up study on antibody dependent cell-mediated cytotoxicity and cell-mediated cytotoxicity to HBs-antigen conjugated target cells in patients with hepatitis B. Klinische Wochenschrift 58(22): 1251-1255, 1980

Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) to Measles Virus Infected Cells. Pediatrics International 23(2): 251-251, 1981