+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Anticoagulant treatment and dilated cardiomyopathy



Anticoagulant treatment and dilated cardiomyopathy



Archives des Maladies du Coeur et des Vaisseaux 88(4 Suppl): 617-621



The prevalence of intracardiac thrombi in patients with dilated cardiomyopathy is very variable from one study to another, but is generally high: 20 to 25% for interatrial thrombi and 50% for intraventricular thrombi. There is also a high incidence of left atrial spontaneous contrast (30-40%). Left atrial thrombosis or spontaneous contrast is more common in atrial fibrillation, when the LA diameter is increased with low velocity intra-left atrial blood flow on Doppler examination and when there are disturbances of haemorrheological factors (increased fibrinogen levels and plasma viscosity). Ventricular thrombi are more common when the fractional shortening is decreased (< 11% = 80% of thrombi). The frequency of embolism is controversial. It varies between 1.4 and 12 events per 100 patients per year. The risk of complications is higher in patients with intracavitary thrombosis. The number of cerebral haemorrhagic complications in patients on long-term oral anticoagulants is far from negligible. Large prospective multicenter trials should be instituted, as for atrial fibrillation to evaluate systematic anticoagulation with respect to the risks. In the meantime, it would seem to be prudent to prescribe oral anticoagulants to all patients with dilated cardiomyopathy with an intracardiac thrombus and/or atrial fibrillation, and to perform echocardiography regularly when left ventricular function is very poor.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042291671

Download citation: RISBibTeXText

PMID: 7487312


Related references

Oral anticoagulant therapy in dilated cardiomyopathy. Warfarin treatment results in subgroups of patients at risk of embolic complications. Giornale Italiano di Cardiologia 25(6): 689-694, 1995

The anticoagulant therapy of patients with dilated cardiomyopathy. Vrachebnoe Delo 1990(11): 46-50, 1990

Anticoagulant therapy in patients with dilated cardiomyopathy. Annali Italiani di Medicina Interna 13(4): 227-232, 1999

Evolution of dilated cardiomyopathy (DCM) from idiopathic hypertrophic cardiomyopathy (IHCM) vs. inflammatory dilated cardiomyopathy (DCMi): a rare case of sudden death in an 8-year-old boy. Pathology Research and Practice 200(5): 411-5; Discussion 417-21, 2004

Evolution of dilated cardiomyopathy from idiopathic hypertrophic cardiomyopathy vs inflammatory dilated cardiomyopathy a rare case of sudden death in an 8-year-old boy. Pathology Research & Practice 200(5): 411-415, 2004

Evolution of dilated cardiomyopathy from idiopathic hypertrophic cardiomyopathy vs inflammatory dilated cardiomyopathy a rare case of sudden death in an 8-year-old boy by R Dettmeyer, P Schmidt, R Kandolf and B Madea, Pathol Res Pract 200 411-415. Pathology Research & Practice 200(5): 417-421, 2004

Features of mildly dilated congestive cardiomyopathy compared with idiopathic restrictive cardiomyopathy and typical dilated cardiomyopathy. Journal of the American Society of Echocardiography 1(1): 78-87, 1988

Comparison of clinical and morphologic cardiac findings in patients having cardiac transplantation for ischemic cardiomyopathy, Idiopathic dilated cardiomyopathy, and dilated hypertrophic cardiomyopathy. American Journal Of Cardiology. 81(7): 884-894, Il 1, 1998

Increased thrombocyte activation in dilated cardiomyopathy: a risk factor for development of ventricular thrombosis despite anticoagulant therapy?. Zeitschrift für Kardiologie 91(5): 423-429, 2002

Usefulness of delayed enhancement magnetic resonance imaging to differentiate dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. Journal of Cardiac Failure 13(5): 372-379, 2007

Clonal T-cell-receptor composition is not associated with enteroviral or adenoviral infection in dilated cardiomyopathy Implications for the pathogenesis of dilated cardiomyopathy. Journal of the American College of Cardiology 43(5 Suppl. A): 204A, 2004

Difference in myocardial flow reserve between patients with dilated cardiomyopathy and those with dilated phase of hypertrophic cardiomyopathy - Evaluation by O-15-water PET. Circulation Journal 71(6): 884-890, 2007

Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. Journal of the American College of Cardiology 55(4): 320-329, 2010