Section 43
Chapter 42,356

Azlocillin concentrations in human aqueous humor after intravenous and subconjunctival administration

Behrens-Baumann, W.; Ansorg, R.

Graefe's Archive for Clinical and Experimental Ophthalmology 220(6): 292-293


ISSN/ISBN: 0721-832X
PMID: 6629022
DOI: 10.1007/bf00231358
Accession: 042355778

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Twenty-nine patients received either 4 g intravenous infusion or 100 mg subconjunctival application of azlocillin 1-12 h before cataract extraction. After intravenous application the mean aqueous humor concentration of azlocillin was 4.4 micrograms/ml after 3 h. The subconjunctival dose produced a mean aqueous humor concentration of 78 micrograms/ml and 3.4 micrograms/ml after 3 and 12 h, respectively. These levels are above the minimum inhibitory concentration of azlocillin for sensitive organisms.

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