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Beta-propiolactone as a sterilizing agent in the manufacture of intravenous immunoglobulin preparations



Beta-propiolactone as a sterilizing agent in the manufacture of intravenous immunoglobulin preparations



Arzneimittel-Forschung 33(9): 1230-1231



It was demonstrated with phi X174, phi e and x phages that the beta-propiolactone step, which eliminated the anticomplementary activity of the intravenous immunoglobulin (IgG) preparation. Intraglobin, inactivates more than 10(6) viruses/ml. This means additional safety with respect to those viral diseases for which specific and sensitive diagnostic methods are not available at present.

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Accession: 042377748

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PMID: 6416260


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