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CRH and the noradrenergic system mediate the antinociceptive effect of central interleukin-1 alpha in the rat



CRH and the noradrenergic system mediate the antinociceptive effect of central interleukin-1 alpha in the rat



Brain Research Bulletin 36(1): 113-117



After intracerebroventricular administration, both interleukin-1 alpha and corticotropin-releasing hormone increase nociceptive thresholds evaluated by the hot-plate test in the rat. Pretreatment with 6-hydroxydopamine or prazosin fully prevents the action of both substances. Moreover, the effect of interleukin-1 alpha is completely blocked by the intracerebroventricular administration of the corticotropin-releasing hormone antagonist alpha-helical CRH 9-41. Our results suggest an involvement of CRH and the noradrenergic system in the antinociceptive effect of central interleukin-1 alpha.

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Accession: 042429171

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PMID: 7882045


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