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CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

American Journal of Psychiatry 138(8): 1098-1101

The authors examined the CSF GABA of 87 subjects: 29 normal control subjects, 11 patients with schizophrenia, 26 with depression, 6 with mania, and 15 with anorexia nervosa. Depressed patients had significantly lower CSF GABA levels than did normal subjects. This finding suggests that GABA may have a direct or indirect association with depressive affective disorders.

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Accession: 042429223

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PMID: 7258390

DOI: 10.1176/ajp.138.8.1098

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