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CSF cation changes following subarachnoid injection of iohexol and metrizamide in rabbits

CSF cation changes following subarachnoid injection of iohexol and metrizamide in rabbits

Acta Radiologica: Diagnosis 25(1): 65-71

Forty anaesthetized rabbits were injected subarachnoidally with equimolal doses, 0.48 mmol/kg body weight (= 185 mg I/kg), of iohexol and metrizamide, administered in solutions iso- and hyperosmolal to the CSF. Concentrations of Na, K, Ca and Mg in the CSF were determined before and 3 hours after the contrast medium injections. Iso-osmolal iohexol caused a uniform decrease in all four cations, which was believed to be a simple dilution. The hyperosmolal solution of iohexol caused a significant relative increase in Ca compared with Na, K and Mg. Both metrizamide solutions caused an increase in Ca over its pre-injection level and a significant relative increase of both Ca and Mg as compared with Na and K. The changes caused by the three latter solutions were consistent with an increase in the blood-brain barrier permeability.

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Accession: 042429252

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PMID: 6547266

DOI: 10.1177/028418518402500113

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