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CSF levels of lactate and hydroxybutyrate dehydrogenase as indicators of neurological sequelae after neonatal brain damage



CSF levels of lactate and hydroxybutyrate dehydrogenase as indicators of neurological sequelae after neonatal brain damage



Developmental Medicine and Child Neurology 23(2): 228-233



A prospective study was made of levels of lactate and hydroxybutyrate dehydrogenase in the blood and cerebrospinal fluid of 57 term neonates, in relation to the time elapsed since delivery, neonatal examinations (Apgar score, neurological symptoms and EEG findings) and psychomotor outcome at one year of age. Serum determinations revealed no significant relationship with clinical assessments. CSF measurements showed significant differences near to the time of delivery between the normal and handicapped groups at age one, which supports the hypothesis of a causal link between neonatal brain damage and CSF enzyme levels.

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Accession: 042429318

Download citation: RISBibTeXText

PMID: 7215710

DOI: 10.1111/j.1469-8749.1981.tb02445.x


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