+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

CSF levels of lactate and hydroxybutyrate dehydrogenase as indicators of neurological sequelae after neonatal brain damage

CSF levels of lactate and hydroxybutyrate dehydrogenase as indicators of neurological sequelae after neonatal brain damage

Developmental Medicine and Child Neurology 23(2): 228-233

A prospective study was made of levels of lactate and hydroxybutyrate dehydrogenase in the blood and cerebrospinal fluid of 57 term neonates, in relation to the time elapsed since delivery, neonatal examinations (Apgar score, neurological symptoms and EEG findings) and psychomotor outcome at one year of age. Serum determinations revealed no significant relationship with clinical assessments. CSF measurements showed significant differences near to the time of delivery between the normal and handicapped groups at age one, which supports the hypothesis of a causal link between neonatal brain damage and CSF enzyme levels.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 042429318

Download citation: RISBibTeXText

PMID: 7215710

DOI: 10.1111/j.1469-8749.1981.tb02445.x

Related references

Cerebro spinal fluid levels of lactate and hydroxy butyrate dehydrogenase as indicators of neurological sequelae after neo natal brain damage. Developmental Medicine & Child Neurology 23(2): 228-233, 1981

Lactate dehydrogenase and alpha hydroxybutyrate dehydrogenase Sensitive indicators of disease status and responsiveness to therapy in adult acute lymphoblastic leukaemia. Saudi Medical Journal 16(2): 99-101, 1995

Serum lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase and ratio of alpha-hydroxybutyrate dehydrogenase to lactate dehydrogenase in testicular tumours. Indian Journal of Cancer 27(4): 243-249, 1990

Serum activities of hydroxybutyrate dehydrogenase (HBD) and the isoenzymes of lactate dehydrogenase (LD) as an index of traumatic brain injury. Acta Neurochirurgica 37(3-4): 245-261, 1977

Lactate dehydrogenase (LD), hydroxybutyrate dehydrogenase (HBD), and LD-isoenzymes in brain tissue. Acta Neurochirurgica 36(1-2): 61-70, 1977

An automated method for the determination of total lactate dehydrogenase, heat-stable lactate dehydrogenase isozyme-1, and hydroxybutyrate dehydrogenase. Journal of Laboratory and Clinical Medicine 67(1): 131-143, 1966

Creatine phosphokinase and lactate dehydrogenase levels after ultra long-distance running. An analysis of iso-enzyme profiles with special reference to indicators of myocardial damage. South African Medical Journal 55(26): 1061-1064, 1979

Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate. Biochemical Journal 234(2): 489-492, 1986

Possibility and limitations of early neurological diagnosis of the sequelae of neonatal cerebral injury. II. Longitudinal study of neonatal cerebral damage in the first 2 years of life. Minerva Pediatrica 19(24): 1175-1182, 1967

Enhancement of lactate fraction in poly(lactate-co-3-hydroxybutyrate) synthesized by Escherichia coli harboring the D-lactate dehydrogenase gene from Lactobacillus acetotolerans HT. Journal of General and Applied Microbiology 2019, 2019

The fate of lactate in isolated cells from early neonatal rat brain. Comparison with glucose and 3-hydroxybutyrate. Biochemical Society Transactions 19(2): 141s, 1991

Enzymatic activities of retina and anthocyanoside extracts of Vaccinium myrtillus (lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, 6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, alpha-glycerophosphate dehydrogenase, 5-nucleotidase, phosphoglucose isomerase). Biochemical Pharmacology 19(7): 2295-2302, 1970

Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. European Respiratory Journal 9(8): 1736-1742, 1996

Early damage indicators in the the lung I. Lactate dehydrogenase activity in the airways. Toxicology and Applied Pharmacology 44(2): 291-297, 1978

Normal values at 37 degrees for serum lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase and glycerate dehydrogenase. Clinica Chimica Acta; International Journal of Clinical Chemistry 46(1): 5-10, 1973