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CSF oligoclonal bands, immunoglobulins, and viral antibodies in progressive myoclonus epilepsy



CSF oligoclonal bands, immunoglobulins, and viral antibodies in progressive myoclonus epilepsy



Archives of Neurology 38(4): 206-208



We studied CSF and serum samples from 16 patients with progressive myoclonus epilepsy (PME). These patients had juvenile-onset PME with evidence of autosomal recessive inheritance and no Lafora bodies. Twelve of the 16 patients with PME had immunologic abnormalities. Oligoclonal gamma bands were seen in six of the eight patients from whom sufficient CSF was available. The CSF albumin and serum/CSF albumin ratios were normal in all 16 patients, indicating the presence of intact blood-brain barriers. Six of the 16 patients showed increased CSF IgG levels and five had an increased CNS IgG synthesis. All patients had normal serum and CSF IgM and IgA levels. Three patients, all with bands, had reduced measles and/or vaccinia serum/CSF antibody ratios. The findings suggest altered immune response of the CNS of some patients with PME apparently caused by nonspecific immunostimulation.

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Accession: 042429336

Download citation: RISBibTeXText

PMID: 6783017

DOI: 10.1001/archneur.1981.00510040032003


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