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CSF perfusion to treat intraventricular penicillin toxicity

CSF perfusion to treat intraventricular penicillin toxicity

Archives of Neurology 38(6): 390-391

A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

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Accession: 042429339

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PMID: 7236074

DOI: 10.1001/archneur.1981.00510060092022

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