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CSF-plasma relationships for DSIP and some other neuropeptides



CSF-plasma relationships for DSIP and some other neuropeptides



Pharmacology, Biochemistry, and Behavior 19(6): 1037-1040



The relationships between CSF and plasma hormonal levels of several peptides were studied in the same samples of simultaneously obtained plasma and CSF. A significant correlation existed between CSF and plasma levels of DSIP as well as gastrin. Preliminary results also showed a correlation between CSF and plasma levels of NT, but not VIP or calcitonin. CSF/plasma ratios and the effect of BBB disruption also varied from peptide to peptide. These diverse CSF/plasma relationships are not easily explained by models of nonspecific passage but may indicate individual systems or axes that could be involved in the central effects of peripherally administered peptides.

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Accession: 042429385

Download citation: RISBibTeXText

PMID: 6689211

DOI: 10.1016/0091-3057(83)90412-4


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