EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Catecholamine sulfates and platelet phenolsulfotransferase activity in essential hypertension


Catecholamine sulfates and platelet phenolsulfotransferase activity in essential hypertension



Journal of Laboratory and Clinical Medicine 104(2): 238-244



ISSN/ISBN: 0022-2143

PMID: 6589333

Because of high plasma concentrations of conjugated catecholamines and their unknown relationship to hypertension, we determined those conjugates more specifically as catecholamine sulfates together with the sulfoconjugating enzyme-phenolsulfotransferase activity in platelets of 62 patients with essential hypertension and 32 normal controls. Our results indicated: (1) that the pool of total (free and sulfated) catecholamines (dopamine, norepinephrine, and epinephrine) is higher (because of an increase in dopamine sulfate levels) but the degree of epinephrine conjugation is lower in patients with essential hypertension compared with controls; (2) that norepinephrine sulfate levels rise with age in both groups, but the increase in free norepinephrine with age observed in controls was not observed in patients with essential hypertension; and (3) that catecholamine conjugates were found to be exclusively sulfates and platelet phenolsulfotransferase activity was not different in both groups. Platelet phenolsulfotransferase activity was, however, positively correlated with plasma norepinephrine sulfate levels, and the degree of sulfoconjugation of norepinephrine was positively correlated with that of dopamine in controls but not in patients with essential hypertension. These abnormalities occurring in essential hypertension in the absence of intergroup differences in platelet phenolsulfotransferase activity suggest that the enzyme is either not a good marker of the overall activity or that other factors account for the observed differences. Thus, additional determinants of the process of generation and degradation of sulfoconjugated catecholamines, some of which may be more stable markers of sympathetic activity than free catecholamines, need to be explored.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042469170

Download citation: RISBibTeXText

Related references

Blood phenolsulfotransferase and monoamine oxidase-B activity in essential arterial hypertension. Archives des Maladies du Coeur et des Vaisseaux 80(6): 816-818, 1987

Tissue distribution of dopamine sulfates and phenolsulfotransferase activity in the dog. Japanese Journal of Pharmacology 39(Suppl): 376P, 1985

Platelet catecholamine content sympathetic tone and adrenergic responsiveness in essential hypertension. Hypertension (Dallas) 20(3): 407, 1992

The contribution of the sympathoadrenomedullary system to the etiology of essential hypertension: a study using plasma and platelet catecholamine concentrations. Journal of Clinical Endocrinology and Metabolism 80(2): 455-460, 1995

The contribution of th sympathoadrenomedullary system to the etiology of essential hypertension : a study using plasma and platelet catecholamine concentrations. The Journal of Clinical Endocrinology and Metabolism 80(2): 455-460, 1995

Platelet phenolsulfotransferase activity in dementia. European Journal of Clinical Investigation 21(2 Part 2): 24, 1991

Platelet phenolsulphotransferase activity and 'abdominal migraine'. Archives of Disease in Childhood 63(12): 1500-1501, 1988

Platelet phenolsulfotransferase activity and the headache spectrum. Psychopharmacology Bulletin 20(3): 539-541, 1984

Gender-related seasonality of human platelet phenolsulfotransferase activity. Neuropsychobiology 38(1): 1-5, 1998

Plasma renin activity severity index and urinary catecholamine in essential hypertension. Journal of the Kansai Medical University 33(3): 453-471, 1981

Dopamine-beta-hydroxylase activity and catecholamine concentrations in plasma: experimental and essential hypertension. Postgraduate Medical Journal 53(Suppl): 43-48, 1977

Essential Hypertension in the Elderly: Haemodynamics, Intravascular Volume, Plasma Renin Activity, and Circulating Catecholamine Levels. The Lancet 322(8357): 983-986, 1983

Essential hypertension in the elderly: haemodynamics, intravascular volume, plasma renin activity, and circulating catecholamine levels. Lancet 2(8357): 983-986, 1983

Investigation of impaired platelet activity in patients with essential hypertension. European Journal of Clinical Investigation 25(Suppl 2): A40, 1995

Platelet calmodulin concentration and phospholipase A2 activity in essential hypertension. Regulatory Peptides. Supplement 4: 144-147, 1985