Cefoperazone concentrations in human aqueous humor after intravenous administration

Axelrod, J.L.; Kochman, R.S.

American Journal of Ophthalmology 94(1): 103-105


ISSN/ISBN: 0002-9394
PMID: 6211988
DOI: 10.1016/0002-9394(82)90200-8
Accession: 042472881

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Twenty-four patients about to undergo elective cataract surgery received either a 2-g (ten patients) or a 4-g (14 patients) intravenous infusion of cefoperazone one to six hours before surgery. The 4-g dose produced a mean peak aqueous humor concentration of 2.93 micrograms/ml at one hour; the mean concentration remained higher than 2 micrograms/ml for at least four hours. These levels, however, were never more than 90% of the minimum inhibitory concentration of cefoperazone for common bacterial ocular pathogens.