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Cellular source of interferon induced in human peripheral blood mononuclear leukocytes by mumps virus or by tumour cells persistently infected with mumps virus



Cellular source of interferon induced in human peripheral blood mononuclear leukocytes by mumps virus or by tumour cells persistently infected with mumps virus



Journal of General Virology 54(Pt 2): 293-299



Human leukocyte interferon (IFN-a) was induced in cultures of human peripheral blood mononuclear leukocytes (PBML) from seropositive healthy donor infected by mumps virus, or by a human lung carcinoma cell line (Pc-10) persistently infected with mumps virus (Pc-10/M-V). Adherent cells (M0), non-T, non-B cells and B cells all produced IFN in response to mumps virus or Pc-10/MpV cells. The non-T, non-B cells co-cultured with Pc-10/MpV cells produced high-titred IFN. However, T cells did not produced any antiviral factors even in the presence of M0. Furthermore, T cells activated with phytohaemagglutinin (PHA-P), concanavalin A or treated with u.v.-irradiated mumps virus, or Pc-10/MpV cells pretreated with mitomycin C did not produce any antiviral factors in response to either mumps virus or Pc-10/MpV cells.

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Accession: 042478479

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PMID: 6169793

DOI: 10.1099/0022-1317-54-2-293


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