Central action of cholecystokinin-pancreozymin and secretin on pancreatic enzyme secretion

Rozin, D.G.

Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 67(9): 1364-1369


ISSN/ISBN: 0015-329X
PMID: 6170532
Accession: 042479192

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In chronic experiments on dogs with fistulae of pancreas, administration of pancreozymin into the cerebral ventricles activated the lipase activity of pancreatic juice whereas secretin inhibited the trypsin activity. The pancreozymin administration into the anterior hypothalamus activated the pancreatic lipase whereas administration of this hormone into the RF exerts no effect on the basal secretion of juice and enzymes. The secretin administration into the hypothalamus or RF leaves the pancreatic secretion intact. Administration of CSF from dogs-donors with pancreozymin in their cisterna magna activated the lipase activity of the juice. Central action of cholecystokinin-pancreozymin on the pancreatic secretion of enzymes seems to be actualized through the hypothalamic structures.