+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Changes in zinc metabolism during long-term D-penicillamine treatment of patients with Wilson-Konovalov disease

Changes in zinc metabolism during long-term D-penicillamine treatment of patients with Wilson-Konovalov disease

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 84(3): 356-359

Using atomic absorption spectrophotometry, the authots determined zink levels (in correlation with the time-course of copper elimination) in the blood serum and urine of 28 patients with hepatocerebral dystrophy prior to and during the first year of D-penicillamine treatment and in 55 patients who had been on this therapy for a number of years. The zink concentration in the patients' blood serum prior to treatment tended to decline. Such a decrease was also noted in cirrhosis of other etiologies. Thiol therapy resulted in a gradual increase in the urine zink elimination which followed a pattern of the drug dose increment and could be two to three times higher than normal in cases of prolonged treatment. Nevertheless, these patients exhibited no symptoms of zink insufficiency and the zink concentration in the blood serum had been normal for a number of years, which may be explained by an enhanced absorption of zink from the intestines and by its mobilization from the tissue depots. The pathological manifestations observed in six patients with the asthenoneurotic syndrome regressed following zink administration.

(PDF emailed within 1 workday: $29.90)

Accession: 042503338

Download citation: RISBibTeXText

PMID: 6720176

Related references

Effects of long-term treatment in Wilson's disease with D-penicillamine and zinc sulphate. Journal of Neurology 243(3): 269-273, 1996

Long-term effects of a combination of D-penicillamine and zinc salts in the treatment of Wilson's disease in children. Experimental and Therapeutic Medicine 5(4): 1129-1132, 2013

Effects of long-term zinc treatment in Japanese patients with Wilson disease: efficacy, stability, and copper metabolism. Translational Research 156(6): 350-357, 2010

The effect of long term treatment with penicillamine on the copper content in the liver in patients with Wilson's disease. Acta Hepato-Gastroenterologica 22(5): 292-296, 1975

The effect of long-term treatment with d-penicillamine on the humoral immune response in patients with Wilson's disease. Materia Medica Polona. Polish Journal of Medicine and Pharmacy 8(1): 48-50, 1976

Use of penicillamine in Wilson-Konovalov disease. Klinicheskaia Meditsina 58(1): 56-60, 1980

Wilson's disease (experience of long-term treatment with penicillamine---con penicilamina. Revista Clinica Espanola 133(5): 451-454, 1974

Long-term treatment of Wilson's disease with D-penicillamine. Report on 20 cases. Deutsche Medizinische Wochenschrift 92(37): 1657-1662, 1967

Fibrosing alveolitis as a complication due to D-penicillamine therapy for Wilson-Konovalov disease. Klinicheskaia Meditsina 82(11): 57-60, 2005

Liver copper determination in long-term treatment of Wilson's disease with D-penicillamine. Die Medizinische Welt 32(3): 109-110, 1981

Treatment with D-penicillamine or zinc sulphate affects copper metabolism and improves but not normalizes antioxidant capacity parameters in Wilson disease. Biometals 27(1): 207-215, 2015

Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine. European Journal of Gastroenterology and Hepatology 22(5): 564-571, 2010

Effect of penicillamine and zinc on iron metabolism in Wilson's disease. Scandinavian Journal of Gastroenterology 42(12): 1495-1500, 2007

Detection of D-penicillamine in skin lesions in a case of dermal elastosis after a previous long-term treatment for Wilson's disease. Journal of the European Academy of Dermatology and Venereology 29(2): 383-386, 2015

Copper and zinc in the serum, urine, and hair of patients with Wilson's disease treated with penicillamine and zinc. Biological Trace Element Research 133(3): 265-269, 2010