Section 43
Chapter 42,504

Changes of blood urea nitrogen and serum creatinine levels following cephaloridine administration

Hasumi, M.; Kashiwagi, K.; Amano, M.

Japanese Journal of Antibiotics 34(7): 1106-1112


ISSN/ISBN: 0368-2781
PMID: 7321190
Accession: 042503673

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The purpose of the study is to evaluate the effect of cephaloridine on renal function, especially blood urea nitrogen and serum creatinine levels in clinical cases. The study was performed in cases given the drug for prophylaxis of postoperative infections and treatment of various infections. Drip infusion of more than 2 g of cephaloridine (Ceporan) for 2 hours was given twice a day to 213 cases. The dose is thought to make it possible to maintain an effective blood level of the drug. Levels of blood urea nitrogen were measured before and after the administration in 197 cases and serum creatinine was measured in 116 out of 197 cases. Elevated levels of blood urea nitrogen were observed in 12 cases while abnormal serum creatinine levels were found in 8 cases. Transient and slight rising of blood urea nitrogen levels was observed in many cases of the prophylactic group due to postoperative catabolism or influence of the surgery. Bases on precise analysis of cases who showed abnormal levels of blood urea nitrogen and serum creatinine, the levels were proved to improve or return to normal and to be unchanged. So that, it is said that the administration of the drug is not necessarily affect the renal function of clinical cases.

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