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Circadian variations in insulin concentrations and blood glucose in non-diabetics as well as insulin requirements in insulin-dependent diabetics

Bruns, W.; Jutzi, E.; Fischer, U.; Bombor, H.; Woltanski, K.P.; Jahr, D.; Wodrig, W.; Albrecht, G.

Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 36(5): 258-260

1981


ISSN/ISBN: 0044-2542
PMID: 7018102
Accession: 042544454

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On the basis of the estimation of the plasma glucose and the insulin concentrations in 10-minute intervals during 24 hours by the mathematical analysis (multiple regression) over relations between the behaviour of plasma glucose and insulin concentration insulin secretion rates independent of plasma glucose can be calculated. In non-diabetics a circadian rhythm of the disposal of insulin - independent of food - is established. Thus the secretion rate increases in the early morning hours still before before the first meal and is maintained in different size up to nearly 18 o'clock. Then it established itself to the level of the nocturnal basal rate. Adequate changes of the insulin need during night are proved in diabetics without endogenic residual insulin secretion by means of the artificial B-cell Biostator. The circadian rhythm of the disposal of insulin take place parallel with adequate changes of other biological parameters and is of importance for the practice of the conventional insulin therapy as well as in the future use of non-measuring value-regulated insulin infusions (open-loop system).

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