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Comparative studies on the serum levels of alpha-1-antitrypsin and alpha-macroglobulin in several mammals

Takahara, H.; Nakamura, Y.; Yamamoto, K.; Sinohara, H.

Tohoku Journal of Experimental Medicine 139(3): 265-270

1983

ISSN/ISBN: 0040-8727
PMID: 6190264
DOI: 10.1620/tjem.139.265
Accession: 042614605
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The sera of human, cattle, horse, sheep, goat, pig, dog, rabbit, guinea pig, rat, hamster, and mouse were assayed for total trypsin-inhibiting capacity, and for concentrations of alpha-1-antitrypsin and alpha-macroglobulin. The rodents examined showed striking species differences: the alpha-1-antitrypsin levels of mouse, rat, and guinea pig were more than twice the human level, while the alpha-macroglobulin levels of hamster and guinea pig were 340 and 40%, respectively, of the human level. On the other hand, little variations were found among the large domestic animals, their levels of the two inhibitors being similar to those of the human.

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