+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of the beta-adrenoceptor blocking activity of oxprenolol, slow release oxprenolol and a combined oxprenolol diuretic preparation



Comparison of the beta-adrenoceptor blocking activity of oxprenolol, slow release oxprenolol and a combined oxprenolol diuretic preparation



British Journal of Clinical Pharmacology 12(6): 869-871



1 Observations were made in five healthy subjects who exercised before and 2, 3, 6, 8 and 24 h after the oral administration on separate occasions of 160 mg oxprenolol, 160 mg slow release oxprenolol, 160 mg slow release oxprenolol with 0.25 mg cyclopenthiazide and placebo. Blood samples were obtained before and at 1, 2, 3, 6, 8, 12 and 24 h after drug administration and assayed for oxprenolol concentration. 2 The three formulations produced maximum reductions of 29% in the exercise tachycardia 3 to 6 h after drug administration. At 24 h the effects of the three preparations were not significantly different from placebo. 3 There were no significant differences in the plasma concentrations produced by the three formulations during the 24 h period. 4 These observations suggest that the slow release formulations of oxprenolol should be given twice daily to maintain cardiac beta-adrenoceptor blockade throughout a period of 24 h.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 042625686

Download citation: RISBibTeXText

PMID: 6122463

DOI: 10.1111/j.1365-2125.1981.tb01323.x


Related references

Comparison of the activity and plasma levels of oxprenolol slow release oxprenolol long acting propranolol and sotalol. European Journal of Clinical Pharmacology 17(6): 419-424, 1980

Comparison of a slow-release formulation of oxprenolol with conventional oxprenolol in the treatment of hypertension. Clinical Science and Molecular Medicine. Suppl. 3: 559s-561s, 1976

A comparison of slow release oxprenolol with conventional oxprenolol in the treatment of hypertension. European Journal of Clinical Pharmacology 14(2): 77-82, 1978

Slow-release oxprenolol compared with oxprenolol in hypertensive patients: a multicenter clinical trial. Drug Intelligence and Clinical Pharmacy 17(1): 51-54, 1983

A comparison of slow Trasicor (oxprenolol 160 mg) and Trasidrex (oxprenolol 160 mg and cyclopenthiazide 0.25 mg) in the treatment of hypertension in general practice. Journal of International Medical Research 9(5): 315-318, 1981

Slow release oxprenolol in angina pectoris: study comparing oxprenolol, once daily, with propranolol, four times daily. American Journal of Cardiology 47(5): 1123-1127, 1981

Effect of slow oxprenolol and a combination of slow oxprenolol and cyclopenthiazide on plasma lipoproteins. Atherosclerosis 39(3): 301-306, 1981

Comparison of beta-adrenoceptor blocking properties of sotalol, oxprenolol, propranolol and pindolol on rabbit intestinal smooth muscle. Pharmacology 13(5): 441-447, 1975

Controlled evaluation of the beta adrenoceptor blocking drug oxprenolol in anxiety. Medical Journal of Australia 1(24): 909-912, 1976

Pre-dosing plasma concentrations and beta-adrenoceptor blocking effects during repeated once daily dosing with 160 mg sustained-release propranolol (Inderal LA) and 16/260 oxprenolol Oros to healthy volunteers. British Journal of Clinical Pharmacology 19 Suppl 2: 197s-201s, 1985

Duration of beta blockade after slow release oxprenolol. Circulation Suppl. 54(2): II-212, 1976

Suppression of conditioned hyper thermic response by l oxprenolol and d oxprenolol in rats. Experientia (Basel) 30(6): 695, 1974

Simultaneous determination of oxprenolol and 2H6-labelled oxprenolol in human plasma by gas chromatography/mass spectrometry. Biomedical Mass Spectrometry 12(6): 269-273, 1985

Inhibition of isoproterenol activation of adenylate cyclase by metoprolol, oxprenolol, and the para isomer of oxprenolol. Molecular Pharmacology 12(2): 203-207, 1976

Pre dosing plasma concentrations and beta adrenoceptor blocking effects during repeated once daily dosing with 160 milligram sustained release propranolol inderal la and 16 260 oxprenolol oros to healthy volunteers. British Journal of Clinical Pharmacology 19(SUPPL 2): 197S-202S, 1985