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Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits


, : Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. Immunopharmacology 5(3): 183-195

We have recently shown that indomethacin and ASA diminish the elevated blood flow, protein exudation, and leukocyte infiltration during acute inflammation induced by killed Escherichia coli, the reversed Arthus reaction, or zymosan-activated plasma (ZAP; C5ades-arg) in rabbit skin. All of these effects were likely due to the inhibition by these drugs of prostaglandin (PG) synthesis in the lesions. Because glucocorticoids are also reported to inhibit PG production and, in large doses, to suppress inflammation accompanying various clinical conditions, we investigated the effects of hydrocortisone (HC), and methylprednisolone (MP), administered in large doses (100 mg/m2/d of MP or 2.5 g/m2/d of HC) on the above three forms of acute inflammation in rabbits. The effect of indomethacin treatment was studied in parallel for comparison. Blood flow, protein exudation, and leukocyte infiltration were quantitated simultaneously with 86Rb Cl, 125I-labelled rabbit albumin and 51Cr labelled blood leukocytes. Systemic indomethacin therapy decreased the blood flow and permeability, while local indomethacin (2.5 micrograms) significantly inhibited leukocyte infiltration into the lesions. In contrast, HC and MP caused only a mild decrease in blood flow, without altering protein exudation or leukocyte influx. However, HC and MP did inhibit protein exudation induced by bradykinin or histamine injection. These results indicate that, at least in rabbits, HC and MP, in contrast to indomethacin, have very weak anti-inflammatory actions on three complement- and neutrophil-mediated inflammatory responses, i.e., E. coli, ZAP (C5ades-arg) and reversed Arthus reactions.

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Accession: 042626359

PMID: 6219968

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Glassman A.; Davis J.M., 1987: Overdose with tricyclic drugs. Psychiatric Annals 17(6): 410-411

Araujo, P., 1966: Helmintos de Rattus norvegicus (Berkenhouts 1769) de cidade de Sao Paulo. Ciencia e Cultura Sao Paulo, 18: 144-145

Satoh, S.; Ohyama, Y.; Hayashi, M., 1981: Effects of renal nerve stimulation, norepinephrine and angiotensin II on renal blood flow in relation to release of PG-like substances in anesthetized dogs. The effects of vasoconstrictor stimulation, renal nerve stimulation or infusion of norepinephrine or angiotensin II into the renal artery, on renal blood flow were determined before and after the administration of indomethacin in pentobarbital-ane...

Fujii, A.; Takita, T.; Shimada, N.; Umezawa, H., 1974: Biosyntheses of new bleomycins. Journal of Antibiotics 27(1): 73-77

Eichner, D., 1954: Treatment with cation exchange substances. Participation of the adrenals. Rats were given either a low-Na diet with 10 per cent. by weight of a cation exchange resin, or drinking water with 2 to 2.5 per cent. NaCl. Deprivation of salt increased activity in the zona glomerulosa of the adrenal cortex and reduced that in t...

Malaisse, W.J.; Rasschaert, J.; Conget, I.; Sener, A., 1991: Hexose metabolism in pancreatic islets. Regulation of aerobic glycolysis and pyruvate decarboxylation. 1. D-Glucose (0.5-16.7 mM) preferentially stimulates aerobic glycolysis and D-[3,4-14C]glucose oxidation, relative to D-[5-3H]glucose utilization in rat pancreatic islets, the concentration dependency of such a preferential effect displaying a sig...

Porter Stephen C., 1966: Late Wisconsin alpine glaciation of east-central Cascade Range, Washington. Special Paper - Geological Society of America Pages 131

Koyama, T., 1979: Studies in the Cyperaceae of Thailand. II. Miscellaneous taxa of Fimbristylideae, Rhynchosporeae, Scirpeae and Sclerieae. Brittonia 31(2): 284-293

ARTHUR, D.R., 1953: The capitulum and feeding mechanism of Ixodes hexagonus Leach. II. The author described the method of skin penetration by I. hexagonus and the skin reaction of the host to tick bites. A " cement " layer, probably a salivary secretion of the tick, precedes the hypostome as it penetrates into the skin.

Masterson, John P.; Bent, Gardner C.; Zarriello, Phillip J.; Granato, Gregory E.; Walter, Donald A.; Waite, Andrew M.; Church, Peter E., 2011: Simulated effects of withdrawals on groundwater flow MODFLOW models. Scientific Investigations Report: 65-84