+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Contrasting effects of activated and nonactivated macrophages and macrophages from tumor-bearing mice on tumor growth in vivo

Contrasting effects of activated and nonactivated macrophages and macrophages from tumor-bearing mice on tumor growth in vivo

Journal of the National Cancer Institute 65(5): 913-920

The effect of macrophages from normal and tumor-bearing mice on tumor growth was investigated with the use of an in vivo neutralization test. Macrophages from unstimulated and thioglycollate-stimulated peritoneal cavities (nonactivated macrophages) of normal mice enhanced growth of various syngeneic tumors [a 3-methylcholanthrene-induced transplantable fibrosarcoma from inbred C3HeB mice, a spontaneously originated transplantable melanoma (B16) from inbred C57BL/6 mice, and a radiation-induced lymphoma from inbred BALB/c mice]. This enhancing effect was not destroyed by irradiation of macrophages and was apparently mediated by macrophage secretory products. The effect appeared to be unrelated to immunosuppression and may have reflected direct stimulation of tumor cells. In contrast, Corynebacterium parvum-activated macrophages markedly inhibited tumor growth. Peritoneal macrophages from fibrosarcoma-bearing mice, which possessed tumor-inhibitory T-lymphocytes, enhanced tumor growth and abolished the effects of the tumor-inhibitory lymphocytes. Clearly, under certain conditions nonactivated macrophages interfered with the mechanisms of T-cell-mediated antitumor resistance in tumor-bearing mice.

(PDF emailed within 1 workday: $29.90)

Accession: 042669506

Download citation: RISBibTeXText

PMID: 6933261

Related references

Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice. Carbohydrate Polymers 198: 302-312, 2018

Enhancement of tumor growth by peritoneal macrophages of normal and tumor-bearing mice. Advances in Experimental Medicine and Biology 121b: 485-491, 1979

Effect of macrophages with different activated phenotypes on tumor growth, lymphangiogenesis and lymph node metastasis in mice bearing Lewis lung carcinoma. 2008

Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice. Frontiers in Physiology 5: 17-17, 2014

Lymphokine activated tumor inhibition in vivo 1. the local administration of interleukin 2 triggers nonreactive lymphocytes from tumor bearing mice to inhibit tumor growth. Journal of Immunology 134(2): 1305-1311, 1985

Role of alveolar macrophages in tumor-bearing rats: tumoricidal properties of carrageenan-activated macrophages. Invasion & Metastasis 8(6): 364-373, 1988

Therapeutic effects on experimental metastatic tumor-bearing mice by vaccination with GM-CSF gene-modified and tumor antigen-pulsed macrophages. Science in China. Series C, Life Sciences 41(1): 107-112, 2008

Response of the rif 1 tumor in vitro and in c 3h km mice to x radiation cell survival re growth delay and tumor control chemo therapeutic agents and activated macrophages. Journal of the National Cancer Institute 64(3): 605-612, 1980

Suppressor macrophages in tumor-bearing mice. Inconsistency between in vivo and in vitro findings?. International Journal of Cancer 29(6): 695-698, 1982

Production of tumor necrosis factor tnf and interleukin 1 il 1 by macrophages in tumor bearing mice and the effects of interleukin 2 il 2. Journal of Leukocyte Biology 42(4): 374-375, 1987

Transfer of tumor immunity by both CD4+ and CD8+ tumor infiltrating T lymphocytes activated in vivo by IL-2 therapy of tumor bearing mice. Immunobiology 188(3): 281-292, 1993

Inhibition of in vitro growth of lymphoma cells by macrophages from tumor-bearing mice. Journal of the National Cancer Institute 55(4): 971-975, 1975

Macrophage function in tumor-bearing mice: tumoricidal and chemotactic responses of macrophages activated by infection with Mycobacterium bovis, strain BCG. Journal of Immunology 118(6): 2176-2181, 1977

The role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. I. Induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF. Journal of Immunology 146(2): 783-789, 1991

Inhibition of tumor growth in vivo by macrophages activated in vitro with lymphocyte mediators. Clinical Research 26(3): 440A, 1978