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Copper levels in cervical mucus of women with copper-bearing and noncopper-bearing intrauterine devices

Randic, L.; Musacchio, I.; Epstein, J.A.

Biology of Reproduction 8(4): 499-503

1973


ISSN/ISBN: 0006-3363
PMID: 4710789
DOI: 10.1093/biolreprod/8.4.499
Accession: 042682638

The copper content of individual cervical mucus samples from 50 women using conventional plastic intrauterine devices (IUDs) and from 50 women using copper-bearing IUDs containing 200 sq. mm copper wire were determined. Both groups of women showed the same pattern of copper levels as normal controls with the lowerst level of copper at ovulation. The women using the copper-bearing IUDs showed a significantly higher copper content in all phases of the cycle. Prolonged use of the copper IUD (7 weeks - 2 years) was associated with a drop in copper levels of the cervical mucus to approximately the levels in women wearing a plastic IUD. It is concluded that changes in cervical mucus copper content are due to local effects of the devices on the reproductive tract.

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