+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Current and future approaches to therapy for multiple myeloma

Current and future approaches to therapy for multiple myeloma

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 22(1): 9-15

ISSN/ISBN: 0385-0684

PMID: 7826084

Multiple myeloma accounts for approximately 10% of hematologic cancers; it is characterized by an uncontrolled malignant growth of plasma cells occurring usually in the bone marrow or sometimes in other body sites as well. Malignant myeloma cells produce monoclonal immunoglobulins appearing as monoclonal spikes in the serum and/or urine. Patients with multiple myeloma suffer from various clinical features including bone destruction, bone marrow suppression, impaired renal function, hypercalcemia, serious infection, and amyloidosis. The combination of melphalan and prednisolone has been used as a standard therapy for this disease for over 30 years. The median survival of patients with multiple myeloma is 2.5-3 years, and only 10% of them survive longer than 10 years. To improve the prognosis for multiple myeloma, some strategies have been attempted. In this article, we introduce combination chemotherapy, interferon therapy, and bone marrow transplantation as newer approaches to therapy for multiple myeloma based on the biological characteristics of intractable multiple myeloma. Future therapeutic approaches are also discussed.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 042708811

Download citation: RISBibTeXText

Related references

Antibody therapy for multiple myeloma: novel approaches and future perspectives. Japanese Journal of Clinical Hematology 61(8): 912-921, 2020

Minimal Residual Disease in Multiple Myeloma: Current Landscape and Future Applications with Immunotherapeutic Approaches. Frontiers in Oncology 10: 860, 2020

Multiple myeloma: current therapy and a glimpse of the future. Scandinavian Journal of Haematology 35(1): 38-47, 1985

Multiple myeloma: the (r)evolution of current therapy and a glance into future. Haematologica 105(10): 2358-2367, 2020

Challenging the current approaches to multiple myeloma-related bone disease: from bisphosphonates to target Therapy. Current Cancer Drug Targets 9(7): 854-870, 2009

Challenging the current approaches to multiple myeloma- and other cancer-related bone diseases: from bisphosphonates to targeted therapy. Leukemia and Lymphoma 53(6): 1057-1061, 2012

Multiple Myeloma: Introduction: Multiple Myeloma Current Approaches. Cancer Investigation 15(1): 55-56, 1997

Management of Myeloma: Current and Future Approaches. Cancer Control: Journal of the Moffitt Cancer Center 5(3): 218-225, 1998

Current approaches for the treatment of multiple myeloma. International Journal of Hematology 97(3): 333-344, 2013

Multiple myeloma: current therapeutic approaches. Bulletin du Cancer 79(3): 231-242, 1992

Current approaches to supportive care in multiple myeloma. Srpski Arhiv Za Celokupno Lekarstvo 139 Suppl. 2: 123-128, 2011

Approaches and Challenges in the Management of Multiple Myeloma in the very Old: Future Treatment Prospects. Frontiers in Medicine 8: 612696, 2021

Current and emerging immunotherapeutic approaches to the treatment of multiple myeloma. Therapeutic Advances in Hematology 10: 2040620719854171, 2019

Peptide-based immunotherapy for multiple myeloma: current approaches. Vaccine 28(37): 5939-5946, 2010

Current approaches to the initial treatment of symptomatic multiple myeloma. International Journal of Hematologic Oncology 2(1), 2013