Cyclic nucleotides and cellular kinetics in normal and abnormal human trophoblastic tissue

Masuko, K.; Tojo, S.

Archives of Gynecology 230(4): 335-344

1981


ISSN/ISBN: 0170-9925
PMID: 6269503
DOI: 10.1007/bf02199683
Accession: 042719884

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Abstract
The ability to synthesize DNA and the cell cycle of normal trophoblastic cells and the trophoblastic cells of hydatidiform moles and invasive moles were studied by the autoradiographic technique. Compared with normal trophoblast, hydatidiform moles or invasive moles had a higher ability to synthesize DNA. cAMP tended to inhibit DNA synthesis in normal and molar tissue, whereas cGMP tended to promote it. The cell cycle time for each type of trophoblastic tissue was roughly 15 h; however, as compared to normal trophoblast, the hydatidiform or invasive moles had a longer S phase and a shorter G1 phase.

Cyclic nucleotides and cellular kinetics in normal and abnormal human trophoblastic tissue