Section 43
Chapter 42,725

Cytogenetic effect of a number of pesticides in a human peripheral blood lymphocyte culture with a varying initial level of chromosome aberrations

Pilinskaia, M.A.

Tsitologiia i Genetika 15(2): 82-84


ISSN/ISBN: 0564-3783
PMID: 7233556
Accession: 042724861

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The paper deals with results of studies in the mutagenic activity of pesticides (polymarzin, cuprozin and pyrimor) in the human peripheral lymphocyte culture at various frequency of "spontaneous" chromosome aberrations. Only pyrimor is determined to possess the cytogenetic action in the used test-system. It is shown that the intensity of the pyrimor-induced cytogenetic effect depends on the initial level of aberrant metaphases in the control cultures obtained from two different persons. The previously made conclusion on the potential mutagenic danger of pyrimor is confirmed on the basis of studies of its cytogenetic activity in mice bone marrow cells.

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