Section 43
Chapter 42,725

Cytogenetic effect of chlordiazepoxide on the bone marrow cells of Swiss mice in vivo

Kar, R.N.; Das, R.K.

Cytobios 36(142): 73-82


ISSN/ISBN: 0011-4529
PMID: 6851658
Accession: 042724864

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Chromosomal preparations were examined for structural and numerical abnormalities induced by chlordiazepoxide (CDZ) in mice which received either a single oral dose (20 mg/kg) or multiple doses (10, 20, 40 and 80 mg/kg) for time-response and dose-response studies, respectively. The sampling was done at different post-treatment hours. The structural aberrations recorded were mostly of the chromatid type. CDZ induced a significant increase in chromosomal aberration frequencies at all sampling hours with a peak at 32 h post-treatment. In dose-response studies all the dose groups showed a significant increase over controls but the effect was maximum at the lowest dose level.

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