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Delayed-alternation performance after selective lesions of the medial and sulcal prefrontal cortex of the guinea pig

Markowitsch, H.J.; Riess, R.

Brain Behavior and Evolution 18(1-2): 96-104

1981


ISSN/ISBN: 0006-8977
PMID: 7237108
DOI: 10.1159/000121779
Accession: 042747462

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The sulcal or medial subdivision of the prefrontal cortex of the guinea pig was ablated after the animals had learned a spatial delayed-alternation task. Retention of this task was significantly impaired only after ablation of the medial prefrontal cortex. As the most critical cortical region for delayed-alternation performance in the rat is also situated in the medial prefrontal cortex, our findings suggest a close functional correspondence of the prefrontal cortices of these rodent species.

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