Section 43
Chapter 42,842

Distribution of lecithin-cholesterol acyltransferase (LCAT) in human plasma lipoprotein fractions. Evidence for the association of active LCAT with low density lipoproteins

Chen, C.H.; Albers, J.J.

Biochemical and Biophysical Research Communications 107(3): 1091-1096


ISSN/ISBN: 0006-291X
PMID: 7138515
DOI: 10.1016/0006-291x(82)90633-7
Accession: 042841521

Download citation:  

The distribution of lecithin-cholesterol acyltransferase (LCAT) in human plasma was assessed by measuring both Lcat mass and activity in plasma fractions separated by sequential flotation ultracentrifugation, single-spin gradient ultracentrifugation, dextran sulfate-Mg2+ precipitation or agarose gel filtration. Although most of the Lcat was found to be associated with the high density lipoprotein fraction, a small amount of active Lcat (approximately 1% of the plasma Lcat mass and activity) was consistently associated with the low density lipoprotein fraction. Lcat was not found in the very low density lipoprotein fraction. The LDL-associated Lcat may play an important role in the acylation of lysolecithin by lysolecithin acyltransferase activity of LCAT.

Full Text Article emailed within 0-6 h: $19.90