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Effect of a combined radiation lesion on the enzyme activity of the glutathione redox system of the rat liver



Effect of a combined radiation lesion on the enzyme activity of the glutathione redox system of the rat liver



Biulleten' Eksperimental'noi Biologii i Meditsiny 95(2): 48-50



A study was made of activity of glutathione peroxidase, glutathione reductase and glutathione-dehydroascorbate oxidoreductase in the rat liver under x-ray treatment in doses of 206 or 155 mC/kg coupled with mechanical injury (closed fracture of the leg bones). Radiation in a dose of 206 mC/kg gave rise to the following changes in activity of glutathione redox-system enzymes: reduced activity of glutathione peroxidase on the 3d day, and increased activity of glutathione reductase, and glutathione-dehydroascorbate oxidoreductase on the 7th day after combined radiation injury. Radiation in a dose of 155 mC/kg was accompanied by increased activity of glutathione-dehydroascorbate oxidoreductase on the 7th day and reduced glutathione reductase activity on the 30th day after the injury infliction.

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Accession: 042890295

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PMID: 6824775


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