Effect of a sulphated glycopeptide on rat gastric acid secretion stimulated by histamine, bethanechol, pentagastrin and dibutyryl cyclic AMP

Niada, R.; Prino, G.

British Journal of Pharmacology 48(3): 550-552

1973


ISSN/ISBN: 0007-1188
PMID: 4357964
DOI: 10.1111/j.1476-5381.1973.tb08362.x
Accession: 042891147

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Abstract
The antisecretory activity of a semisynthetic sulphated glycopeptide (GLPS) was studied in rats in which the secretion rates of gastric acid were detennined on the perfused stomach preparation. GLPS at 1 mg/kg i.v. reduced the hypersecretory effect of dibutyryl cyclic AMP, histamine, pentagastrin, bethanechol but not of theophylline.

Effect of a sulphated glycopeptide on rat gastric acid secretion stimulated by histamine, bethanechol, pentagastrin and dibutyryl cyclic AMP