Effect of furosemide and aminophylline in experimental acute post-ischemic renal failure

Shimizu, M.H.; Seguro, A.C.; Monteiro, J.L.; Rocha, A.d.S.

Revista do Hospital das Clinicas 37(2): 56-60


ISSN/ISBN: 0041-8781
PMID: 7134735
Accession: 042908637

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The effect of furosemide and aminophylline in the recovery of acute renal failure was evaluated in rats in which renal ischemia was induced by clamping the aorta above and below the left renal artery; the right kidney served as control. The administration of high doses of furosemide (100 mg/kg body wt) before induction of renal ischemia did not prevent the decrease in glomerular filtration rate (GFR) and the oliguric effect. Injection of furosemide in 8 other animals after the renal ischemia did not increase the GFR (0.24 .+-. 0.04 to 0.23 .+-. 0.04 ml/min) produced only a rise inl urine output and Na+ excretion in 6 of the amimals. The administration of aminophylline, an inhibitor of adenosine, a renal vasoconstrictor substance produced during renal ischemia, did not increase the GFR (0.09 .+-. 0.04 to 0.10 .+-. 0.02 ml/min), or produce any change in H2O and solute excretion. Evidently, furosemide and aminophylline do not exert a significant protection against the GFR fall in experimental acute renal failure, and furosemide can only convert an oliguric renal failure to nonoliguric.