Effect of human leukocyte interferon on human lymphocytes in vitro: cytogenetic studies
Sørensen, J.P.; Jensen, M.K.; Jersild, C.
Mutation Research 90(2): 143-147
ISSN/ISBN: 0027-5107 PMID: 6173748 DOI: 10.1016/0165-1218(81)90077-x
Mitogen-stimulated lymphocytes from 8 healthy donors were exposed to interferon, and cytogenetic studies were preformed. The response of lymphocytes to the mitogens phytohemagglutinin (PHA), concanavalin A (con A) and pokeweed mitogen (PWM) was inhibited by interferon, whereas an increased number of structural chromosomal aberrations was not detected. Further investigations of the cytogenetic effects of interferon are needed.