Effect of hydrocortisone and cholinolytics on the resistance of rat erythrocytes to hypoosmotic hemolysis

Nezhentsev, M.V.

Farmakologiia i Toksikologiia 44(2): 188-191


ISSN/ISBN: 0014-8318
PMID: 7274426
Accession: 042911643

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It was shown in experiments in vitro that hydrocortisone, gangleron and benzohexonium at a concentration of 10(-6) M increase the resistance of rat red cells to hypoosmotic hemolysis. Diplacin, d-tubocurarin, methamysil and methacin at the same concentration produce no effect on the resistance. Repeated injections of hydrocortisone to rats decrease the osmotic resistance of red cells, while diplacin and d-tubocurarin increase it. Combined use of hydrocortisone and cholinolytics made it possible to reveal the ability of diplacin and d-tubocurarin to reduce the effect of the steroid on the osmotic resistance of red cells both in vitro and in vivo.